![]() Moderate-to-high heritability estimates and a varying immune response for different cow types regarding their susceptibility to BDD support the influence of host genetic factors ( Scholey et al., 2012 Gomez et al., 2014). The use of the well-established M-scoring system ( Döpfer et al., 1997) can be applied to record frequency and progress of affected animals for an assessment of risk factors influencing BDD in a herd as well as for genetic evaluations ( Schöpke et al., 2015 Tremblay et al., 2016). Systems for standardized recording of disease stages have been developed to describe visual changes and pain in the skin as well as the response to treatment ( Döpfer et al., 1997 Shearer and Hernandez, 2000). New strategies for prevention of BDD are needed, given that no efficient vaccines exist to date ( Evans et al., 2014), and the application of (topical) antibiotics and chemicals in footbaths induces bacterial resistances, pollutes the environment, and negatively impacts the health of the operator ( Laven and Logue, 2006 Speijers et al., 2010). In addition to economic effects for the affected herds, a negative impact on performance and well-being of cattle has been described. The disease has been reported as a worldwide problem in dairy cows and beef cattle ( Orsel et al., 2018). is highly probable ( Evans et al., 2014 Zinicola et al., 2015). ![]() Even though the pathogenesis of BDD has not been completely determined yet, a multifactorial etiology and influence of several microbes with a primary impact of Treponema spp. BDD is difficult to manage as it is persistent, has different clinical manifestations, and high recurrence after therapy ( Berry et al., 2012). The disease has become one of the most common claw diseases associated with severe lameness in cattle. Results might be implemented in cattle-breeding programs and could pave the way for the establishment of a BDD prescreening test.īovine digital dermatitis (BDD), first described over 40 years ago ( Cheli and Mortellaro, 1974), is an infectious disease of the bovine foot, frequently occurring in the plantar skin bordering the interdigital cleft of the rear leg ( Holzhauer et al., 2008). Our study provides an insight into the genomic background for a genetic predisposition related to the pathogenesis of BDD. Specific genotypes were significantly more likely to be affected by BDD and developed chronic lesions. A sequence analysis of the chromosomal regions revealed rs208894039 and rs109521151 polymorphisms as having significant influence on susceptibility to the disease. Significant associations for single-nucleotide polymorphisms were found near genes CMPK2 (chromosome 11) and ASB16 (chromosome 19) both being implicated in immunological processes. We used 5,040 genotyped animals with phenotype information based on the M-stage system for genome-wide association. With our study, we identified genomic regions with the impact on occurrence and development of BDD. 3Institute of Veterinary Medicine, Georg-August-University Göttingen, Göttingen, Germanyīovine digital dermatitis (BDD) is an infectious disease of the hoof in cattle with multifactorial etiology and a polygenic influence on susceptibility.2Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, United States.1Group Animal Breeding, Institute of Agricultural and Nutritional Sciences, Martin-Luther-University Halle-Wittenberg, Halle, Germany.Diana Oelschlaegel 1 Monika Wensch-Dorendorf 1 Grit Kopke 1 Roswitha Jungnickel 1 Benno Waurich 1 Frank Rosner 1 Dörte Döpfer 2 Bertram Brenig 3 Hermann H.
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